CD38
O CD38 (também conhecido como T10) é uma ectoenzima multifuncional cujo gene codificador localiza-se no braço curto do cromossomo 4 (na espécie Homo sapiens). É amplamente expressa nas células e tecidos humanos, especialmente nos leucócitos.
Possui participação na adesão celular, transdução de sinais e nas vias de sinalização que envolvem o cálcio.
Leitura de apoio[editar | editar código-fonte]
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. PMID 16544364. doi:10.1002/dmrr.626 - Partidá-Sánchez S, Rivero-Nava L, Shi G, Lund FE (2007). «CD38: an ecto-enzyme at the crossroads of innate and adaptive immune responses.». Adv. Exp. Med. Biol. 590: 171–83. PMID 17191385. doi:10.1007/978-0-387-34814-8_12
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- Ferrero E, Malavasi F (1997). «Human CD38, a leukocyte receptor and ectoenzyme, is a member of a novel eukaryotic gene family of nicotinamide adenine dinucleotide+-converting enzymes: extensive structural homology with the genes for murine bone marrow stromal cell antigen 1 and aplysian ADP-ribosyl cyclase.». J. Immunol. 159 (8): 3858–65. PMID 9378973
- Deaglio S, Morra M, Mallone R; et al. (1998). «Human CD38 (ADP-ribosyl cyclase) is a counter-receptor of CD31, an Ig superfamily member.». J. Immunol. 160 (1): 395–402. PMID 9551996
- Yagui K, Shimada F, Mimura M; et al. (1998). «A missense mutation in the CD38 gene, a novel factor for insulin secretion: association with Type II diabetes mellitus in Japanese subjects and evidence of abnormal function when expressed in vitro.». Diabetologia. 41 (9): 1024–8. PMID 9754820. doi:10.1007/s001250051026
