DYNC1I1

Cadeia intermédia 1 da dineina 1 citoplasmática
Identificadores
Símbolos	DYNC1I1; DNCI1; DNCIC1
IDs externos	OMIM: 603772 MGI: 107743 HomoloGene: 68398 GeneCards: DYNC1I1 Gene
Ontologia do gene
Função molecular	•motor activity; •microtubule motor activity; •protein binding; •microtubule binding;
Componente celular	•kinetochore; •condensed chromosome kinetochore; •spindle pole; •citosol; •cytoplasmic dynein complex; •microtubule; •vesicle; •perinuclear region of cytoplasm;
Processo biológico	•antigen processing and presentation of exogenous peptide antigen via MHC class II; •vesicle transport along microtubule;
	Sources: Amigo / QuickGO
Padrões de expressão do ARN
	Mais dados de expressão
Ortólogos
	v; d; e;

editar

Cadeia intermédia 1 da dineina 1 citoplasmática é uma proteína que nos humanos é codificada pelo gene DYNC1I1^[1]^[2]^[3]

Em células melanocíticas, a regulação do gene DYNC1I1 pode ser regulada pelo MTF.^[4]

Interacções[editar | editar código-fonte]

Foi demonstrada a interacção de DYNC1I1 com DYNLL1.^[5]

Referências

↑ Crackower MA, Sinasac DS, Xia J, Motoyama J, Prochazka M, Rommens JM, Scherer SW, Tsui LC (1999). «Cloning and characterization of two cytoplasmic dynein intermediate chain genes in mouse and human». Genomics. 55 (3): 257–67. PMID 10049579. doi:10.1006/geno.1998.5665
↑ Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (2005). «Cytoplasmic dynein nomenclature». J Cell Biol. 171 (3): 411–3. PMC 2171247. PMID 16260502. doi:10.1083/jcb.200508078
↑ «Entrez Gene: DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1»
↑ Hoek KS, Schlegel NC, Eichhoff OM; et al. (2008). «Novel MITF targets identified using a two-step DNA microarray strategy». Pigment Cell Melanoma Res. 21 (6): 665–76. PMID 19067971. doi:10.1111/j.1755-148X.2008.00505.x
↑ Diefenbach, Russell J; Diefenbach Eve, Douglas Mark W, Cunningham Anthony L (2002). «The heavy chain of conventional kinesin interacts with the SNARE proteins SNAP25 and SNAP23». United States. Biochemistry. 41 (50): 14906–15. ISSN 0006-2960. PMID 12475239. doi:10.1021/bi026417u

Leitura adicional[editar | editar código-fonte]

King SM, Dillman JF, Benashski SE; et al. (1997). «The mouse t-complex-encoded protein Tctex-1 is a light chain of brain cytoplasmic dynein.». J. Biol. Chem. 271 (50): 32281–7. PMID 8943288. doi:10.1074/jbc.271.50.32281
Lo KW, Naisbitt S, Fan JS; et al. (2001). «The 8-kDa dynein light chain binds to its targets via a conserved (K/R)XTQT motif.». J. Biol. Chem. 276 (17): 14059–66. PMID 11148209. doi:10.1074/jbc.M010320200
Horikawa I, Parker ES, Solomon GG, Barrett JC (2001). «Upregulation of the gene encoding a cytoplasmic dynein intermediate chain in senescent human cells.». J. Cell. Biochem. 82 (3): 415–21. PMID 11500918. doi:10.1002/jcb.1169
Karki S, Ligon LA, DeSantis J; et al. (2002). «PLAC-24 is a cytoplasmic dynein-binding protein that is recruited to sites of cell-cell contact.». Mol. Biol. Cell. 13 (5): 1722–34. PMC 111139. PMID 12006665. doi:10.1091/mbc.02-02-0011
Strausberg RL, Feingold EA, Grouse LH; et al. (2003). «Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.». Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899
Scherer SW, Cheung J, MacDonald JR; et al. (2003). «Human chromosome 7: DNA sequence and biology.». Science. 300 (5620): 767–72. PMC 2882961. PMID 12690205. doi:10.1126/science.1083423
Hillier LW, Fulton RS, Fulton LA; et al. (2003). «The DNA sequence of human chromosome 7.». Nature. 424 (6945): 157–64. PMID 12853948. doi:10.1038/nature01782
Ota T, Suzuki Y, Nishikawa T; et al. (2004). «Complete sequencing and characterization of 21,243 full-length human cDNAs.». Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285
Ligon LA, Tokito M, Finklestein JM; et al. (2004). «A direct interaction between cytoplasmic dynein and kinesin I may coordinate motor activity.». J. Biol. Chem. 279 (18): 19201–8. PMID 14985359. doi:10.1074/jbc.M313472200
Villacé P, Marión RM, Ortín J (2004). «The composition of Staufen-containing RNA granules from human cells indicates their role in the regulated transport and translation of messenger RNAs.». Nucleic Acids Res. 32 (8): 2411–20. PMC 419443. PMID 15121898. doi:10.1093/nar/gkh552
Chuang JZ, Yeh TY, Bollati F; et al. (2005). «The dynein light chain Tctex-1 has a dynein-independent role in actin remodeling during neurite outgrowth.». Dev. Cell. 9 (1): 75–86. PMID 15992542. doi:10.1016/j.devcel.2005.04.003
Rual JF, Venkatesan K, Hao T; et al. (2005). «Towards a proteome-scale map of the human protein-protein interaction network.». Nature. 437 (7062): 1173–8. PMID 16189514. doi:10.1038/nature04209

[pmid10049579-1] Crackower MA, Sinasac DS, Xia J, Motoyama J, Prochazka M, Rommens JM, Scherer SW, Tsui LC (1999). «Cloning and characterization of two cytoplasmic dynein intermediate chain genes in mouse and human». Genomics. 55 (3): 257–67. PMID 10049579. doi:10.1006/geno.1998.5665

[pmid16260502-2] Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (2005). «Cytoplasmic dynein nomenclature». J Cell Biol. 171 (3): 411–3. PMC 2171247. PMID 16260502. doi:10.1083/jcb.200508078

[entrez-3] «Entrez Gene: DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1»

[pmid19067971-4] Hoek KS, Schlegel NC, Eichhoff OM; et al. (2008). «Novel MITF targets identified using a two-step DNA microarray strategy». Pigment Cell Melanoma Res. 21 (6): 665–76. PMID 19067971. doi:10.1111/j.1755-148X.2008.00505.x

[pmid12475239-5] Diefenbach, Russell J; Diefenbach Eve, Douglas Mark W, Cunningham Anthony L (2002). «The heavy chain of conventional kinesin interacts with the SNARE proteins SNAP25 and SNAP23». United States. Biochemistry. 41 (50): 14906–15. ISSN 0006-2960. PMID 12475239. doi:10.1021/bi026417u

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