GPX5

GPX5
Estruturas disponíveis
PDB	Pesquisa Human UniProt: PDBe RCSB
Lista de códigos id do PDB
	2I3Y
Identificadores
Nomes alternativos	GPX5, glutationa peroxidase secretora epididimal, Glutathione peroxidase 5
IDs externos	OMIM: 603435 HomoloGene: 1155 GeneCards: GPX5
Ontologia genética
Função molecular	• oxidoreductase activity; • peroxidase activity; • glutathione peroxidase activity;
Componente celular	• sperm plasma membrane; • extracellular region; • extracellular space;
Processo biológico	• cellular oxidant detoxification; • GO:0001306 response to oxidative stress; • metabolismo dos lipídios; • cellular response to oxidative stress;
	Sources:Amigo / QuickGO
Ortólogos
	2880
	n/a
	ENSG00000257770; ENSG00000224586
	n/a
	O75715
	n/a
	NM_001509; NM_003996
	n/a
	NP_001500; NP_003987
	n/a
	Wikidata
Ver/Editar Humano

Glutationa peroxidase 5, também conhecida como glutationa peroxidase secretora epididimal, é uma enzima que em humanos é codificada pelo gene GPX5.^[2]^[3]

GPx-5 pertence à família da glutationa peroxidase. É especificamente expresso no epidídimo no trato reprodutivo masculino dos mamíferos e é regulado por andrógenos. Ao contrário dos mRNAs para outras glutationa peroxidases caracterizadas, este mRNA não contém um códon de selenocisteína (UGA). Assim, a proteína codificada é independente do selênio, e foi proposto que desempenhe um papel na proteção das membranas dos espermatozóides dos efeitos prejudiciais da peroxidação lipídica e/ou prevenção da reação acrossômica prematura. Variantes transcritas em splicing alternativo que codificam diferentes isoformas foram descritas para este gene.^[2]

Referências

↑ «Human PubMed Reference:»
↑ ^a ^b «Entrez Gene: glutathione peroxidase 5 (epididymal androgen-related protein)»
↑ Hall L, Williams K, Perry AC, Frayne J, Jury JA (julho 1998). «The majority of human glutathione peroxidase type 5 (GPX5) transcripts are incorrectly spliced: implications for the role of GPX5 in the male reproductive tract». Biochem. J. 333 (1): 5–9. PMC 1219548. PMID 9639555. doi:10.1042/bj3330005

Leitura adicional[editar | editar código-fonte]

Talmud PJ, Drenos F, Shah S, et al. (2009). «Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.». Am. J. Hum. Genet. 85 (5): 628–42. PMC 2775832. PMID 19913121. doi:10.1016/j.ajhg.2009.10.014
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Perry AC, Jones R, Niang LS, et al. (1992). «Genetic evidence for an androgen-regulated epididymal secretory glutathione peroxidase whose transcript does not contain a selenocysteine codon.». Biochem. J. 285 (3): 863–70. PMC 1132876. PMID 1386734. doi:10.1042/bj2850863
Richard MJ, Guiraud P, Didier C, et al. (2001). «Human immunodeficiency virus type 1 Tat protein impairs selenoglutathione peroxidase expression and activity by a mechanism independent of cellular selenium uptake: consequences on cellular resistance to UV-A radiation.». Arch. Biochem. Biophys. 386 (2): 213–20. PMID 11368344. doi:10.1006/abbi.2000.2197
Opalenik SR, Ding Q, Mallery SR, Thompson JA (1998). «Glutathione depletion associated with the HIV-1 TAT protein mediates the extracellular appearance of acidic fibroblast growth factor.». Arch. Biochem. Biophys. 351 (1): 17–26. PMID 9501919. doi:10.1006/abbi.1997.0566
Hartley JL, Temple GF, Brasch MA (2000). «DNA cloning using in vitro site-specific recombination.». Genome Res. 10 (11): 1788–95. PMC 310948. PMID 11076863. doi:10.1101/gr.143000
Rejraji H, Vernet P, Drevet JR (2002). «GPX5 is present in the mouse caput and cauda epididymidis lumen at three different locations.». Mol. Reprod. Dev. 63 (1): 96–103. PMID 12211066. doi:10.1002/mrd.10136
Ota T, Suzuki Y, Nishikawa T, et al. (2004). «Complete sequencing and characterization of 21,243 full-length human cDNAs.». Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285
Choi J, Liu RM, Kundu RK, et al. (2000). «Molecular mechanism of decreased glutathione content in human immunodeficiency virus type 1 Tat-transgenic mice.». J. Biol. Chem. 275 (5): 3693–8. PMID 10652368. doi:10.1074/jbc.275.5.3693
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). «Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.». Genome Res. 16 (1): 55–65. PMC 1356129. PMID 16344560. doi:10.1101/gr.4039406
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). «Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.». Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899
Vernet P, Faure J, Dufaure JP, Drevet JR (1997). «Tissue and developmental distribution, dependence upon testicular factors and attachment to spermatozoa of GPX5, a murine epididymis-specific glutathione peroxidase.». Mol. Reprod. Dev. 47 (1): 87–98. PMID 9110319. doi:10.1002/(SICI)1098-2795(199705)47:1<87::AID-MRD12>3.0.CO;2-X
Price TO, Ercal N, Nakaoke R, Banks WA (2005). «HIV-1 viral proteins gp120 and Tat induce oxidative stress in brain endothelial cells.». Brain Res. 1045 (1–2): 57–63. PMID 15910762. doi:10.1016/j.brainres.2005.03.031
Williams K, Frayne J, Hall L (1998). «Expression of extracellular glutathione peroxidase type 5 (GPX5) in the rat male reproductive tract.». Mol. Hum. Reprod. 4 (9): 841–8. PMID 9783843. doi:10.1093/molehr/4.9.841
Bailey SD, Xie C, Do R, et al. (2010). «Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.». Diabetes Care. 33 (10): 2250–3. PMC 2945168. PMID 20628086. doi:10.2337/dc10-0452
Moyer AM, Sun Z, Batzler AJ, et al. (2010). «Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy.». Cancer Epidemiol. Biomarkers Prev. 19 (3): 811–21. PMC 2837367. PMID 20200426. doi:10.1158/1055-9965.EPI-09-0871

[1] «Human PubMed Reference:»

[entrez-2] «Entrez Gene: glutathione peroxidase 5 (epididymal androgen-related protein)»

[pmid9639555-3] Hall L, Williams K, Perry AC, Frayne J, Jury JA (julho 1998). «The majority of human glutathione peroxidase type 5 (GPX5) transcripts are incorrectly spliced: implications for the role of GPX5 in the male reproductive tract». Biochem. J. 333 (1): 5–9. PMC 1219548. PMID 9639555. doi:10.1042/bj3330005

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