CRHBP

Corticotropin releasing hormone binding protein
Identificadores
Símbolos	CRHBP; CRF-BP; CRFBP
IDs externos	OMIM: 122559 MGI: 88497 HomoloGene: 1418 ChEMBL: 5930 GeneCards: CRHBP Gene
Ontologia do gene
Função molecular	•protein binding; •peptide binding; •corticotropin-releasing hormone binding;
Componente celular	•extracellular space; •intracellular; •núcleo; •secondary lysosome; •multivesicular body; •endoplasmic reticulum; •Golgi apparatus; •microtubule; •secretory granule; •dendrite; •dense core granule; •varicosity; •perikaryon; •axon terminus;
Processo biológico	•synaptic transmission, dopaminergic; •maternal aggressive behavior; •resposta inflamatória; •signal transduction; •female pregnancy; •behavior; •learning or memory; •hormone-mediated signaling pathway; •cellular response to stress; •cellular response to drug; •cellular response to potassium ion; •hormone metabolic process; •regulated secretory pathway; •behavioral response to ethanol; •regulation of behavior; •regulation of corticotropin secretion; •negative regulation of corticotropin secretion; •cellular response to calcium ion; •cellular response to cocaine; •cellular response to cAMP; •cellular response to tumor necrosis factor; •cellular response to estrogen stimulus; •cellular response to estradiol stimulus; •cellular response to gonadotropin-releasing hormone; •negative regulation of corticotropin-releasing hormone receptor activity; •regulation of N-methyl-D-aspartate selective glutamate receptor activity;
	Sources: Amigo / QuickGO
Padrões de expressão do ARN
	Mais dados de expressão
Ortólogos
	v; d; e;

CRHBP (do inglês: corticotropin releasing hormone binding protein) é uma proteína que nos seres humanos é codificada pelo gene CRHBP.^[1]^[2]

A hormona libertadora da corticotrofina (CRH) é um potente estimulante da síntese e secreção de péptidos derivados de preopiomelanocortina. Apesar de as concentrações de CRH na circulação periférica humana serem normalmente baixas, ela aumenta ao longo da gravidez e cai rapidamente após o parto. A CRH plasmática maternal é provavelmente originária da placenta. O plasma humano contém uma proteína de ligação a CRH que inactiva a CRH e pode prevenir estimulação pituitária-adrenal inapropriada, na gravidez.^[1]

Referências

↑ ^a ^b «Entrez Gene: CRHBP corticotropin releasing hormone binding protein»
↑ Behan DP, Potter E, Lewis KA, Jenkins NA, Copeland N, Lowry PJ, Vale WW (Junho 1993). «Cloning and structure of the human corticotrophin releasing factor-binding protein gene (CRHBP)». Genomics. 16 (1): 63–8. PMID 8198617. doi:10.1006/geno.1993.1141

Leitura de apoio

Behan DP, De Souza EB, Lowry PJ,; et al. (1996). «Corticotropin releasing factor (CRF) binding protein: a novel regulator of CRF and related peptides.». Frontiers in neuroendocrinology. 16 (4): 362–82. PMID 8557170. doi:10.1006/frne.1995.1013
Westphal NJ, Seasholtz AF (2006). «CRH-BP: the regulation and function of a phylogenetically conserved binding protein.». Front. Biosci. 11: 1878–91. PMID 16368564. doi:10.2741/1931
Potter E, Behan DP, Fischer WH,; et al. (1991). «Cloning and characterization of the cDNAs for human and rat corticotropin releasing factor-binding proteins.». Nature. 349 (6308): 423–6. PMID 1846945. doi:10.1038/349423a0
Behan DP, Linton EA, Lowry PJ (1989). «Isolation of the human plasma corticotrophin-releasing factor-binding protein.». J. Endocrinol. 122 (1): 23–31. PMID 2549150. doi:10.1677/joe.0.1220023
Behan DP, Heinrichs SC, Troncoso JC,; et al. (1995). «Displacement of corticotropin releasing factor from its binding protein as a possible treatment for Alzheimer's disease.». Nature. 378 (6554): 284–7. PMID 7477348. doi:10.1038/378284a0
Vamvakopoulos NC, Sioutopoulou TO, Durkin SA,; et al. (1995). «Mapping the human corticotropin releasing hormone binding protein gene (CRHBP) to the long arm of chromosome 5 (5q11.2-q13.3).». Genomics. 25 (1): 325–7. PMID 7774945. doi:10.1016/0888-7543(95)80151-B
Maruyama K, Sugano S (1994). «Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.». Gene. 138 (1-2): 171–4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8
Fischer WH, Behan DP, Park M,; et al. (1994). «Assignment of disulfide bonds in corticotropin-releasing factor-binding protein.». J. Biol. Chem. 269 (6): 4313–6. PMID 8307998
Donaldson CJ, Sutton SW, Perrin MH,; et al. (1996). «Cloning and characterization of human urocortin.». Endocrinology. 137 (5): 2167–70. PMID 8612563. doi:10.1210/en.137.5.2167
Asakura H, Zwain IH, Yen SS (1997). «Expression of genes encoding corticotropin-releasing factor (CRF), type 1 CRF receptor, and CRF-binding protein and localization of the gene products in the human ovary.». J. Clin. Endocrinol. Metab. 82 (8): 2720–5. PMID 9253360. doi:10.1210/jc.82.8.2720
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K,; et al. (1997). «Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.». Gene. 200 (1-2): 149–56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3
Strausberg RL, Feingold EA, Grouse LH,; et al. (2003). «Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.». Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899
Wetzka B, Sehringer B, Schäfer WR,; et al. (2004). «Expression patterns of CRH, CRH receptors, and CRH binding protein in human gestational tissue at term.». Exp. Clin. Endocrinol. Diabetes. 111 (3): 154–61. PMID 12784189. doi:10.1055/s-2003-39778
Claes S, Villafuerte S, Forsgren T,; et al. (2003). «The corticotropin-releasing hormone binding protein is associated with major depression in a population from Northern Sweden.». Biol. Psychiatry. 54 (9): 867–72. PMID 14573312. doi:10.1016/S0006-3223(03)00425-6
Sehringer B, Zahradnik HP, Simon M,; et al. (2005). «mRNA expression profiles for corticotrophin-releasing hormone, urocortin, CRH-binding protein and CRH receptors in human term gestational tissues determined by real-time quantitative RT-PCR.». J. Mol. Endocrinol. 32 (2): 339–48. PMID 15072543. doi:10.1677/jme.0.0320339
Gerhard DS, Wagner L, Feingold EA,; et al. (2004). «The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).». Genome Res. 14 (10B): 2121–7. PMC 528928. PMID 15489334. doi:10.1101/gr.2596504
Herringa RJ, Roseboom PH, Kalin NH (2006). «Decreased amygdala CRF-binding protein mRNA in post-mortem tissue from male but not female bipolar and schizophrenic subjects.». Neuropsychopharmacology. 31 (8): 1822–31. PMID 16482088. doi:10.1038/sj.npp.1301038

[entrez-1] «Entrez Gene: CRHBP corticotropin releasing hormone binding protein»

[pmid8198617-2] Behan DP, Potter E, Lewis KA, Jenkins NA, Copeland N, Lowry PJ, Vale WW (Junho 1993). «Cloning and structure of the human corticotrophin releasing factor-binding protein gene (CRHBP)». Genomics. 16 (1): 63–8. PMID 8198617. doi:10.1006/geno.1993.1141

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