DYNLT1

DYNLT1
Identificadores
Nomes alternativos	DYNLT1, Cadeia leve de dineína tipo Tctex 1, TCTEX1
IDs externos	OMIM: 601554 HomoloGene: 4754 GeneCards: DYNLT1
Ontologia genética
Função molecular	• GO:0001948, GO:0016582 ligação a proteínas plasmáticas; • identical protein binding; • cytoskeletal motor activity; • protein C-terminus binding;
Componente celular	• citoplasma; • complexo de Golgi; • secretory vesicle; • fuso mitótico; • dynein complex; • cytoplasmic microtubule; • microtúbulo; • citoesqueleto; • host cell; • extracellular region; • cytoplasmic dynein complex; • secretory granule lumen; • ficolin-1-rich granule lumen; • mitocôndria; • lamellipodium; • soma; • axonal growth cone;
Processo biológico	• intracellular transport of viral protein in host cell; • regulation of G protein-coupled receptor signaling pathway; • negative regulation of neurogenesis; • nervous system development; • divisão celular; • establishment of mitotic spindle orientation; • microtubule-dependent intracellular transport of viral material towards nucleus; • viral entry into host cell; • ciclo celular; • GO:0022415 viral process; • transport of viral material towards nucleus; • neutrophil degranulation; • positive regulation of neuron projection development; • dendrite development; • positive regulation of Rac protein signal transduction; • negative regulation of mitochondrial membrane permeability; • GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity; • neuron projection morphogenesis; • regulation of cytoskeleton organization; • negative regulation of cell death; • axon development;
	Sources:Amigo / QuickGO
Padrão de expressão RNA
	Mais dados de referência de expressão
Ortólogos
	6993
	n/a
	ENSG00000146425
	n/a
	P63172
	n/a
	NM_006519; NM_001291602; NM_001291603
	n/a
	NP_001278531; NP_001278532; NP_006510
	n/a
	Wikidata
Ver/Editar Humano

A Cadeia leve de dineína tipo TCTEX1 é uma proteína que em humanos é codificada pelo gene DYNLT1.^[2]^[3]^[4]

A dineína citoplasmática é o principal complexo de proteína motora responsável por processos móveis baseados em microtúbulos e de extremidade inferior. Cada complexo de dineína consiste em 2 cadeias pesadas que possuem ATPase e atividades motoras, além de um grupo de polipeptídeos acessórios. TCTEX1 é uma cadeia leve de dineína envolvida na ligação de carga (Chuang et al., 2005).^[4]

Referências

↑ «Human PubMed Reference:»
↑ Watanabe TK, Fujiwara T, Shimizu F, Okuno S, Suzuki M, Takahashi E, Nakamura Y, Hirai Y (julho de 1996). «Cloning, expression, and mapping of TCTEL1, a putative human homologue of murine Tcte1, to 6q». Cytogenet Cell Genet. 73 (1–2): 153–6. PMID 8646886. doi:10.1159/000134329
↑ Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (novembro de 2005). «Cytoplasmic dynein nomenclature». J Cell Biol. 171 (3): 411–3. PMC 2171247. PMID 16260502. doi:10.1083/jcb.200508078
↑ ^a ^b «Entrez Gene: DYNLT1 dynein, light chain, Tctex-type 1»

Leitura adicional

Tete R, de Montgolfier R, Piante M (1971). «[Leiomyoma and leiomyosarcoma of the small intestine. Value of selective angiography]». Journal de Médecine de Lyon. 52 (192): 1523–6 passim. PMID 5503857
King SM, Dillman JF, Benashski SE, et al. (1997). «The mouse t-complex-encoded protein Tctex-1 is a light chain of brain cytoplasmic dynein.». J. Biol. Chem. 271 (50): 32281–7. PMID 8943288. doi:10.1074/jbc.271.50.32281
Nagano F, Orita S, Sasaki T, et al. (1998). «Interaction of Doc2 with tctex-1, a light chain of cytoplasmic dynein. Implication in dynein-dependent vesicle transport.». J. Biol. Chem. 273 (46): 30065–8. PMID 9804756. doi:10.1074/jbc.273.46.30065
Strovel ET, Wu D, Sussman DJ (2000). «Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription.». J. Biol. Chem. 275 (4): 2399–403. PMID 10644691. doi:10.1074/jbc.275.4.2399
Mueller S, Cao X, Welker R, Wimmer E (2002). «Interaction of the poliovirus receptor CD155 with the dynein light chain Tctex-1 and its implication for poliovirus pathogenesis.». J. Biol. Chem. 277 (10): 7897–904. PMID 11751937. doi:10.1074/jbc.M111937200
Schwarzer C, Barnikol-Watanabe S, Thinnes FP, Hilschmann N (2002). «Voltage-dependent anion-selective channel (VDAC) interacts with the dynein light chain Tctex1 and the heat-shock protein PBP74.». Int. J. Biochem. Cell Biol. 34 (9): 1059–70. PMID 12009301. doi:10.1016/S1357-2725(02)00026-2
Nadano D, Nakayama J, Matsuzawa S, et al. (2002). «Human tastin, a proline-rich cytoplasmic protein, associates with the microtubular cytoskeleton.». Biochem. J. 364 (Pt 3): 669–77. PMC 1222615. PMID 12049630. doi:10.1042/BJ20011836
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). «Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.». Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899
Machado RD, Rudarakanchana N, Atkinson C, et al. (2004). «Functional interaction between BMPR-II and Tctex-1, a light chain of Dynein, is isoform-specific and disrupted by mutations underlying primary pulmonary hypertension.». Hum. Mol. Genet. 12 (24): 3277–86. PMID 14583445. doi:10.1093/hmg/ddg365
Douglas MW, Diefenbach RJ, Homa FL, et al. (2004). «Herpes simplex virus type 1 capsid protein VP26 interacts with dynein light chains RP3 and Tctex1 and plays a role in retrograde cellular transport.». J. Biol. Chem. 279 (27): 28522–30. PMID 15117959. doi:10.1074/jbc.M311671200
Ohka S, Matsuda N, Tohyama K, et al. (2004). «Receptor (CD155)-dependent endocytosis of poliovirus and retrograde axonal transport of the endosome.». J. Virol. 78 (13): 7186–98. PMC 421661. PMID 15194795. doi:10.1128/JVI.78.13.7186-7198.2004
Gerhard DS, Wagner L, Feingold EA, et al. (2004). «The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).». Genome Res. 14 (10B): 2121–7. PMC 528928. PMID 15489334. doi:10.1101/gr.2596504
de Wit NJ, Verschuure P, Kappé G, et al. (2005). «Testis-specific human small heat shock protein HSPB9 is a cancer/testis antigen, and potentially interacts with the dynein subunit TCTEL1.». Eur. J. Cell Biol. 83 (7): 337–45. PMID 15503857. doi:10.1078/0171-9335-00396
Chuang JZ, Yeh TY, Bollati F, et al. (2005). «The dynein light chain Tctex-1 has a dynein-independent role in actin remodeling during neurite outgrowth.». Dev. Cell. 9 (1): 75–86. PMC 3857739. PMID 15992542. doi:10.1016/j.devcel.2005.04.003
Yeh TY, Peretti D, Chuang JZ, et al. (2007). «Regulatory dissociation of Tctex-1 light chain from dynein complex is essential for the apical delivery of rhodopsin.». Traffic. 7 (11): 1495–502. PMC 3873093. PMID 16956385. doi:10.1111/j.1600-0854.2006.00482.x

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[1] «Human PubMed Reference:»

[pmid8646886-2] Watanabe TK, Fujiwara T, Shimizu F, Okuno S, Suzuki M, Takahashi E, Nakamura Y, Hirai Y (julho de 1996). «Cloning, expression, and mapping of TCTEL1, a putative human homologue of murine Tcte1, to 6q». Cytogenet Cell Genet. 73 (1–2): 153–6. PMID 8646886. doi:10.1159/000134329

[pmid16260502-3] Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (novembro de 2005). «Cytoplasmic dynein nomenclature». J Cell Biol. 171 (3): 411–3. PMC 2171247. PMID 16260502. doi:10.1083/jcb.200508078

[entrez-4] «Entrez Gene: DYNLT1 dynein, light chain, Tctex-type 1»

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