HLA-DQA2

HLA-DQA2
Identificadores
Nomes alternativos	HLA-DQA2, HLA-DXA, Antígeno de histocompatibilidade HLA de classe II, cadeia alfa DQ (6)
IDs externos	OMIM: 613503 HomoloGene: 134076 GeneCards: HLA-DQA2
Ontologia genética
Função molecular	• MHC class II receptor activity;
Componente celular	• integral component of membrane; • endocytic vesicle membrane; • clathrin-coated endocytic vesicle membrane; • endossoma; • complexo de Golgi; • trans-Golgi network membrane; • endoplasmic reticulum membrane; • membrane; • Golgi membrane; • membrana plasmática; • transport vesicle membrane; • integral component of plasma membrane; • MHC class II protein complex; • lysosomal membrane; • retículo endoplasmático; • ER to Golgi transport vesicle membrane; • lisossoma; • integral component of lumenal side of endoplasmic reticulum membrane; • endosome membrane;
Processo biológico	• antigen processing and presentation; • antigen processing and presentation of exogenous peptide antigen via MHC class II; • interferon-gamma-mediated signaling pathway; • processo do sistema imunitário; • antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 resposta imunitária; • T cell receptor signaling pathway; • adaptive immune response;
	Sources:Amigo / QuickGO
Padrão de expressão RNA
	Mais dados de referência de expressão
Ortólogos
	3118
	n/a
ENSG00000231823; ENSG00000206301; ENSG00000257473; ENSG00000231526; ENSG00000225103;
	ENSG00000237541; ENSG00000223793; ENSG00000233192
	n/a
	P01906
	n/a
	NM_020056
	n/a
	NP_064440
	n/a
	Wikidata
Ver/Editar Humano

Antígeno de histocompatibilidade HLA de classe II, cadeia alfa DQ (6) é uma proteína que em humanos é codificada pelo gene HLA-DQA2. Também conhecido como HLA-DXA ou DAAP-381D23.2, faz parte do sistema de antígenos leucocitários humanos.^[2]

A proteína codificada por este gene é expressa, mas diferentemente do HLA-DQA1, aparentemente incapaz de heterodimerizar com os parálogos da cadeia beta de HLA classe II.^[3] O baixo nível de expressão de HLA-DQA2 é aparentemente devido à ligação deficiente do fator de transcrição ao promotor do gene HLA-DQA2.^[4]

Referências

↑ «Human PubMed Reference:»
↑ «Entrez Gene: HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2»
↑ Rudy GB, Lew AM (março de 1997). «The nonpolymorphic MHC class II isotype, HLA-DQA2, is expressed on the surface of B lymphoblastoid cells». J. Immunol. 158 (5): 2116–25. PMID 9036956
↑ Indovina P, Megiorni F, Fontemaggi G, Coni P, Mora B, Mazzilli MC (maio de 2001). «Absence of in vivo DNA-protein interactions in the DQA2 and DQB2 promoter regions». Hum. Immunol. 62 (5): 504–8. PMID 11334674. doi:10.1016/S0198-8859(01)00236-1

Leitura adicional

Marsh SG, Bodmer JG (1993). «HLA class II nucleotide sequences, 1992.». Tissue Antigens. 40 (5): 229–43. PMID 1362295. doi:10.1111/j.1399-0039.1992.tb02050.x
Kenter M, Otting N, Anholts J, et al. (1992). «Evolutionary relationships among the primate Mhc-DQA1 and DQA2 alleles.». Immunogenetics. 36 (2): 71–8. PMID 1612647. doi:10.1007/BF00215282
Piatier-Tonneau D, Gastinel LN, Amblard F, et al. (1991). «Interaction of CD4 with HLA class II antigens and HIV gp120.». Immunogenetics. 34 (2): 121–8. PMID 1869305. doi:10.1007/BF00211424
Rosenstein Y, Burakoff SJ, Herrmann SH (1990). «HIV-gp120 can block CD4-class II MHC-mediated adhesion.». J. Immunol. 144 (2): 526–31. PMID 1967269
Bowman MR, MacFerrin KD, Schreiber SL, Burakoff SJ (1991). «Identification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex molecules». Proc. Natl. Acad. Sci. U.S.A. 87 (22): 9052–6. PMC 55099. PMID 1978941. doi:10.1073/pnas.87.22.9052
Gyllensten UB, Erlich HA (1990). «Ancient roots for polymorphism at the HLA-DQ alpha locus in primates». Proc. Natl. Acad. Sci. U.S.A. 86 (24): 9986–90. PMC 298627. PMID 2513578. doi:10.1073/pnas.86.24.9986
Clayton LK, Sieh M, Pious DA, Reinherz EL (1989). «Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding». Nature. 339 (6225): 548–51. PMID 2543930. doi:10.1038/339548a0
Diamond DC, Sleckman BP, Gregory T, et al. (1988). «Inhibition of CD4+ T cell function by the HIV envelope protein, gp120». J. Immunol. 141 (11): 3715–7. PMID 2846691
Jonsson AK, Hyldig-Nielsen JJ, Servenius B, et al. (1987). «Class II genes of the human major histocompatibility complex. Comparisons of the DQ and DX alpha and beta genes». J. Biol. Chem. 262 (18): 8767–77. PMID 3036828
Horn GT, Bugawan TL, Long CM, et al. (1988). «Sequence analysis of HLA class II genes from insulin-dependent diabetic individuals». Hum. Immunol. 21 (4): 249–63. PMID 3372263. doi:10.1016/0198-8859(88)90034-1
Andrieu JM, Even P, Venet A (1986). «AIDS and related syndromes as a viral-induced autoimmune disease of the immune system: an anti-MHC II disorder. Therapeutic implications». AIDS research. 2 (3): 163–74. PMID 3489470. doi:10.1089/aid.1.1986.2.163
Auffray C, Lillie JW, Korman AJ, et al. (1987). «Structure and expression of HLA-DQ alpha and -DX alpha genes: interallelic alternate splicing of the HLA-DQ alpha gene and functional splicing of the HLA-DQ alpha gene using a retroviral vector». Immunogenetics. 26 (1–2): 63–73. PMID 3610256. doi:10.1007/bf00345456
Trowsdale J, Lee J, Carey J, et al. (1983). «Sequences related to HLA-DR alpha chain on human chromosome 6: restriction enzyme polymorphism detected with DC alpha chain probes». Proc. Natl. Acad. Sci. U.S.A. 80 (7): 1972–6. PMC 393734. PMID 6300884. doi:10.1073/pnas.80.7.1972
Auffray C, Lillie JW, Arnot D, et al. (1984). «Isotypic and allotypic variation of human class II histocompatibility antigen alpha-chain genes». Nature. 308 (5957): 327–33. PMID 6584734. doi:10.1038/308327a0
Houlgatte R, Scarmato P, el Marhomy S, et al. (1994). «HLA class II antigens and the HIV envelope glycoprotein gp120 bind to the same face of CD4». J. Immunol. 152 (9): 4475–88. PMID 7512597
Chirmule N, McCloskey TW, Hu R, et al. (1995). «HIV gp120 inhibits T cell activation by interfering with expression of costimulatory molecules CD40 ligand and CD80 (B71)». J. Immunol. 155 (2): 917–24. PMID 7541827
Rowell JF, Stanhope PE, Siliciano RF (1995). «Endocytosis of endogenously synthesized HIV-1 envelope protein. Mechanism and role in processing for association with class II MHC». J. Immunol. 155 (1): 473–88. PMID 7602119
Rudy G, Lew AM (1994). «Limited polymorphism of the HLA-DQA2 promoter and identification of a variant octamer». Hum. Immunol. 39 (3): 225–9. PMID 8026991. doi:10.1016/0198-8859(94)90264-X
Chen YH, Böck G, Vornhagen R, et al. (1994). «HIV-1 gp41 binding proteins and antibodies to gp41 could inhibit enhancement of human Raji cell MHC class I and II expression by gp41». Mol. Immunol. 31 (13): 977–82. PMID 8084338. doi:10.1016/0161-5890(94)90092-2
Chirmule N, Wang XP, Hu R, et al. (1994). «Envelope glycoproteins of HIV-1 interfere with T-cell-dependent B cell differentiation: role of CD4-MHC class II interaction in the effector phase of T cell help». Cell. Immunol. 155 (1): 169–82. PMID 8168144. doi:10.1006/cimm.1994.1110

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[1] «Human PubMed Reference:»

[entrez-2] «Entrez Gene: HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2»

[pmid9036956-3] Rudy GB, Lew AM (março de 1997). «The nonpolymorphic MHC class II isotype, HLA-DQA2, is expressed on the surface of B lymphoblastoid cells». J. Immunol. 158 (5): 2116–25. PMID 9036956

[pmid11334674-4] Indovina P, Megiorni F, Fontemaggi G, Coni P, Mora B, Mazzilli MC (maio de 2001). «Absence of in vivo DNA-protein interactions in the DQA2 and DQB2 promoter regions». Hum. Immunol. 62 (5): 504–8. PMID 11334674. doi:10.1016/S0198-8859(01)00236-1

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