HSF1
Aspeto
Fator de choque térmico 1 é uma proteína que em humanos é codificada pelo gene HSF1.[2]
Função
[editar | editar código-fonte]O HSF1, assim como o gene relacionado HSF2, codifica uma proteína que se liga especificamente ao elemento de choque térmico[3] e é altamente conservado em eucariotos e é o mediador primário das respostas transcricionais ao estresse proteotóxico, com papéis importantes na regulação não relacionada ao estresse, como o desenvolvimento e o metabolismo.[4]
Referências
- ↑ «Human PubMed Reference:»
- ↑ Rabindran SK, Giorgi G, Clos J, Wu C (agosto de 1991). «Molecular cloning and expression of a human heat shock factor, HSF1». Proceedings of the National Academy of Sciences of the United States of America. 88 (16): 6906–10. PMC 52202
. PMID 1871105. doi:10.1073/pnas.88.16.6906
- ↑ Vihervaara A, Sistonen L (janeiro de 2014). «HSF1 at a glance». Journal of Cell Science (em inglês). 127 (Pt 2): 261–6. PMID 24421309. doi:10.1242/jcs.132605
- ↑ Anckar J, Sistonen L (15 de junho de 2011). «Regulation of HSF1 function in the heat stress response: implications in aging and disease». Annual Review of Biochemistry (em inglês). 80 (1): 1089–115. PMID 21417720. doi:10.1146/annurev-biochem-060809-095203
Leitura adicional
[editar | editar código-fonte]- Voellmy R (1996). Sensing stress and responding to stress. Exs. 77. [S.l.: s.n.] pp. 121–37. ISBN 978-3-0348-9901-7. PMID 8856972. doi:10.1007/978-3-0348-9088-5_9
- Abravaya K, Myers MP, Murphy SP, Morimoto RI (julho de 1992). «The human heat shock protein hsp70 interacts with HSF, the transcription factor that regulates heat shock gene expression». Genes & Development. 6 (7): 1153–64. PMID 1628823. doi:10.1101/gad.6.7.1153
- Schuetz TJ, Gallo GJ, Sheldon L, Tempst P, Kingston RE (agosto de 1991). «Isolation of a cDNA for HSF2: evidence for two heat shock factor genes in humans». Proceedings of the National Academy of Sciences of the United States of America. 88 (16): 6911–5. PMC 52203
. PMID 1871106. doi:10.1073/pnas.88.16.6911
- Nunes SL, Calderwood SK (agosto de 1995). «Heat shock factor-1 and the heat shock cognate 70 protein associate in high molecular weight complexes in the cytoplasm of NIH-3T3 cells». Biochemical and Biophysical Research Communications. 213 (1): 1–6. PMID 7639722. doi:10.1006/bbrc.1995.2090
- Maruyama K, Sugano S (janeiro de 1994). «Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides». Gene. 138 (1–2): 171–4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8
- Chu B, Soncin F, Price BD, Stevenson MA, Calderwood SK (novembro de 1996). «Sequential phosphorylation by mitogen-activated protein kinase and glycogen synthase kinase 3 represses transcriptional activation by heat shock factor-1». The Journal of Biological Chemistry. 271 (48): 30847–57. PMID 8940068. doi:10.1074/jbc.271.48.30847
- Fukunaga R, Hunter T (abril de 1997). «MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates». The EMBO Journal. 16 (8): 1921–33. PMC 1169795
. PMID 9155018. doi:10.1093/emboj/16.8.1921
- Nair SC, Toran EJ, Rimerman RA, Hjermstad S, Smithgall TE, Smith DF (dezembro de 1996). «A pathway of multi-chaperone interactions common to diverse regulatory proteins: estrogen receptor, Fes tyrosine kinase, heat shock transcription factor Hsf1, and the aryl hydrocarbon receptor». Cell Stress & Chaperones. 1 (4): 237–50. PMC 376461
. PMID 9222609. doi:10.1379/1466-1268(1996)001<0237:APOMCI>2.3.CO;2
- Huang J, Nueda A, Yoo S, Dynan WS (outubro de 1997). «Heat shock transcription factor 1 binds selectively in vitro to Ku protein and the catalytic subunit of the DNA-dependent protein kinase». The Journal of Biological Chemistry. 272 (41): 26009–16. PMID 9325337. doi:10.1074/jbc.272.41.26009
- Cotto J, Fox S, Morimoto R (dezembro de 1997). «HSF1 granules: a novel stress-induced nuclear compartment of human cells». Journal of Cell Science. 110 ( Pt 23) (23): 2925–34. PMID 9359875
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (outubro de 1997). «Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library». Gene. 200 (1–2): 149–56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3
- Shi Y, Mosser DD, Morimoto RI (março de 1998). «Molecular chaperones as HSF1-specific transcriptional repressors». Genes & Development. 12 (5): 654–66. PMC 316571
. PMID 9499401. doi:10.1101/gad.12.5.654
- Satyal SH, Chen D, Fox SG, Kramer JM, Morimoto RI (julho de 1998). «Negative regulation of the heat shock transcriptional response by HSBP1». Genes & Development. 12 (13): 1962–74. PMC 316975
. PMID 9649501. doi:10.1101/gad.12.13.1962
- Zhou X, Tron VA, Li G, Trotter MJ (agosto de 1998). «Heat shock transcription factor-1 regulates heat shock protein-72 expression in human keratinocytes exposed to ultraviolet B light». The Journal of Investigative Dermatology. 111 (2): 194–8. PMID 9699716. doi:10.1046/j.1523-1747.1998.00266.x
- Zou J, Guo Y, Guettouche T, Smith DF, Voellmy R (agosto de 1998). «Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1». Cell. 94 (4): 471–80. PMID 9727490. doi:10.1016/S0092-8674(00)81588-3
- Stephanou A, Isenberg DA, Nakajima K, Latchman DS (janeiro de 1999). «Signal transducer and activator of transcription-1 and heat shock factor-1 interact and activate the transcription of the Hsp-70 and Hsp-90beta gene promoters». The Journal of Biological Chemistry. 274 (3): 1723–8. PMID 9880553. doi:10.1074/jbc.274.3.1723
- Dai R, Frejtag W, He B, Zhang Y, Mivechi NF (junho de 2000). «c-Jun NH2-terminal kinase targeting and phosphorylation of heat shock factor-1 suppress its transcriptional activity». The Journal of Biological Chemistry. 275 (24): 18210–8. PMID 10747973. doi:10.1074/jbc.M000958200
- Choi Y, Asada S, Uesugi M (maio de 2000). «Divergent hTAFII31-binding motifs hidden in activation domains». The Journal of Biological Chemistry. 275 (21): 15912–6. PMID 10821850. doi:10.1074/jbc.275.21.15912