LATS1

LATS1
Estruturas disponíveis
PDB	Pesquisa Human UniProt: PDBe RCSB
Lista de códigos id do PDB
	4ZRK, 5BRK, 5B5W
Identificadores
Nomes alternativos	LATS1
IDs externos	OMIM: 603473 HomoloGene: 55843 GeneCards: LATS1
Ontologia genética
Função molecular	• nucleotide binding; • GO:0001948, GO:0016582 ligação a proteínas plasmáticas; • protein kinase binding; • protein kinase activity; • kinase activity; • transferase activity; • metal ion binding; • magnesium ion binding; • protein serine/threonine kinase activity; • ATP binding; • estrogen receptor binding;
Componente celular	• centro organizador dos microtúbulos; • spindle pole; • citoplasma; • citoesqueleto; • citosol;
Processo biológico	• ciclo celular; • fosforilação; • G2/M transition of mitotic cell cycle; • regulation of actin filament polymerization; • inner cell mass cell fate commitment; • keratinocyte differentiation; • negative regulation of cyclin-dependent protein serine/threonine kinase activity; • regulation of organ growth; • GO:0106159 regulation of protein-containing complex assembly; • cytoplasmic sequestering of protein; • sister chromatid segregation; • positive regulation of apoptotic process; • negative regulation of canonical Wnt signaling pathway; • inner cell mass cellular morphogenesis; • divisão celular; • positive regulation of peptidyl-serine phosphorylation; • hippo signaling; • protein phosphorylation; • hormone-mediated signaling pathway; • regulation of intracellular estrogen receptor signaling pathway; • mammary gland epithelial cell differentiation; • regulation of ubiquitin-dependent protein catabolic process; • GO:0007067 mitose; • G1/S transition of mitotic cell cycle; • GO:0035404 peptidyl-serine phosphorylation; • GO:0007243 intracellular signal transduction;
	Sources:Amigo / QuickGO
Padrão de expressão RNA
	Mais dados de referência de expressão
Ortólogos
	9113
	n/a
	ENSG00000131023
	n/a
	O95835; Q6PJG3
	n/a
	NM_001270519; NM_004690; NM_001350339; NM_001350340; NM_001350392
	n/a
	NP_001257448; NP_004681; NP_001337268; NP_001337269; NP_001337321
	n/a
	Wikidata
Ver/Editar Humano

A grande supressora de tumor quinase 1 (LATS1) é uma enzima que em humanos é codificada pelo gene LATS1.^[2]^[3]^[4]

Ele foi associado à via de sinalização Hippo.^[5]^[6]^[7]

Interações[editar | editar código-fonte]

O LATS1 demonstrou interagir com Zyxin^[8] e Cdk1.^[2]

Referências

↑ «Human PubMed Reference:»
↑ ^a ^b Tao W, Zhang S, Turenchalk GS, Stewart RA, St John MA, Chen W, Xu T (fevereiro de 1999). «Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity». Nat Genet. 21 (2): 177–81. PMID 9988268. doi:10.1038/5960
↑ Iida S, Hirota T, Morisaki T, Marumoto T, Hara T, Kuninaka S, Honda S, Kosai K, Kawasuji M, Pallas DC, Saya H (julho de 2004). «Tumor suppressor WARTS ensures genomic integrity by regulating both mitotic progression and G1 tetraploidy checkpoint function». Oncogene. 23 (31): 5266–74. PMID 15122335. doi:10.1038/sj.onc.1207623
↑ «Entrez Gene: LATS1 LATS, large tumor suppressor, homolog 1 (Drosophila)»
↑ Saucedo LJ, Edgar BA (agosto de 2007). «Filling out the Hippo pathway». Nature Reviews. Molecular Cell Biology. 8 (8): 613–21. PMID 17622252. doi:10.1038/nrm2221
↑ Zhao B, Tumaneng K, Guan KL (agosto de 2011). «The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal». Nature Cell Biology. 13 (8): 877–83. PMC 3987945. PMID 21808241. doi:10.1038/ncb2303
↑ Hao Y, Chun A, Cheung K, Rashidi B, Yang X (fevereiro de 2008). «Tumor suppressor LATS1 is a negative regulator of oncogene YAP». J. Biol. Chem. 283 (9): 5496–509. PMID 18158288. doi:10.1074/jbc.M709037200
↑ Hirota, T; Morisaki T; Nishiyama Y; Marumoto T; Tada K; Hara T; Masuko N; Inagaki M; Hatakeyama K; Saya H (maio de 2000). «Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor». J. Cell Biol. 149 (5): 1073–86. ISSN 0021-9525. PMC 2174824. PMID 10831611. doi:10.1083/jcb.149.5.1073

Leitura adicional[editar | editar código-fonte]

Xu T, Wang W, Zhang S, et al. (1995). «Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase.». Development. 121 (4): 1053–63. PMID 7743921
St John MA, Tao W, Fei X, et al. (1999). «Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction.». Nat. Genet. 21 (2): 182–6. PMID 9988269. doi:10.1038/5965
Nishiyama Y, Hirota T, Morisaki T, et al. (1999). «A human homolog of Drosophila warts tumor suppressor, h-warts, localized to mitotic apparatus and specifically phosphorylated during mitosis.». FEBS Lett. 459 (2): 159–65. PMID 10518011. doi:10.1016/S0014-5793(99)01224-7
Hirota T, Morisaki T, Nishiyama Y, et al. (2000). «Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor.». J. Cell Biol. 149 (5): 1073–86. PMC 2174824. PMID 10831611. doi:10.1083/jcb.149.5.1073
Morisaki T, Hirota T, Iida S, et al. (2002). «WARTS tumor suppressor is phosphorylated by Cdc2/cyclin B at spindle poles during mitosis.». FEBS Lett. 529 (2–3): 319–24. PMID 12372621. doi:10.1016/S0014-5793(02)03360-4
Hisaoka M, Tanaka A, Hashimoto H (2002). «Molecular alterations of h-warts/LATS1 tumor suppressor in human soft tissue sarcoma». Lab. Invest. 82 (10): 1427–35. PMID 12379777. doi:10.1097/01.lab.0000032381.68634.ca
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). «Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences». Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899
Kamikubo Y, Takaori-Kondo A, Uchiyama T, Hori T (2003). «Inhibition of cell growth by conditional expression of kpm, a human homologue of Drosophila warts/lats tumor suppressor». J. Biol. Chem. 278 (20): 17609–14. PMID 12624101. doi:10.1074/jbc.M211974200
Brill LM, Salomon AR, Ficarro SB, et al. (2004). «Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry». Anal. Chem. 76 (10): 2763–72. PMID 15144186. doi:10.1021/ac035352d
Yang X, Yu K, Hao Y, et al. (2004). «LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1». Nat. Cell Biol. 6 (7): 609–17. PMID 15220930. doi:10.1038/ncb1140
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). «Large-scale characterization of HeLa cell nuclear phosphoproteins». Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. PMC 514446. PMID 15302935. doi:10.1073/pnas.0404720101
Gerhard DS, Wagner L, Feingold EA, et al. (2004). «The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)». Genome Res. 14 (10B): 2121–7. PMC 528928. PMID 15489334. doi:10.1101/gr.2596504
Chan EH, Nousiainen M, Chalamalasetty RB, et al. (2005). «The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1». Oncogene. 24 (12): 2076–86. PMID 15688006. doi:10.1038/sj.onc.1208445
Takahashi Y, Miyoshi Y, Takahata C, et al. (2005). «Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers». Clin. Cancer Res. 11 (4): 1380–5. PMID 15746036. doi:10.1158/1078-0432.CCR-04-1773
Kuninaka S, Nomura M, Hirota T, et al. (2005). «The tumor suppressor WARTS activates the Omi / HtrA2-dependent pathway of cell death». Oncogene. 24 (34): 5287–98. PMID 16007220. doi:10.1038/sj.onc.1208682
Bothos J, Tuttle RL, Ottey M, et al. (2005). «Human LATS1 is a mitotic exit network kinase». Cancer Res. 65 (15): 6568–75. PMID 16061636. doi:10.1158/0008-5472.CAN-05-0862
Jiang Z, Li X, Hu J, et al. (2007). «Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma». Neurosci. Res. 56 (4): 450–8. PMID 17049657. doi:10.1016/j.neures.2006.09.006

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[1] «Human PubMed Reference:»

[pmid9988268-2] Tao W, Zhang S, Turenchalk GS, Stewart RA, St John MA, Chen W, Xu T (fevereiro de 1999). «Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity». Nat Genet. 21 (2): 177–81. PMID 9988268. doi:10.1038/5960

[pmid15122335-3] Iida S, Hirota T, Morisaki T, Marumoto T, Hara T, Kuninaka S, Honda S, Kosai K, Kawasuji M, Pallas DC, Saya H (julho de 2004). «Tumor suppressor WARTS ensures genomic integrity by regulating both mitotic progression and G1 tetraploidy checkpoint function». Oncogene. 23 (31): 5266–74. PMID 15122335. doi:10.1038/sj.onc.1207623

[entrez-4] «Entrez Gene: LATS1 LATS, large tumor suppressor, homolog 1 (Drosophila)»

[5] Saucedo LJ, Edgar BA (agosto de 2007). «Filling out the Hippo pathway». Nature Reviews. Molecular Cell Biology. 8 (8): 613–21. PMID 17622252. doi:10.1038/nrm2221

[6] Zhao B, Tumaneng K, Guan KL (agosto de 2011). «The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal». Nature Cell Biology. 13 (8): 877–83. PMC 3987945. PMID 21808241. doi:10.1038/ncb2303

[pmid18158288-7] Hao Y, Chun A, Cheung K, Rashidi B, Yang X (fevereiro de 2008). «Tumor suppressor LATS1 is a negative regulator of oncogene YAP». J. Biol. Chem. 283 (9): 5496–509. PMID 18158288. doi:10.1074/jbc.M709037200

[pmid10831611-8] Hirota, T; Morisaki T; Nishiyama Y; Marumoto T; Tada K; Hara T; Masuko N; Inagaki M; Hatakeyama K; Saya H (maio de 2000). «Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor». J. Cell Biol. 149 (5): 1073–86. ISSN 0021-9525. PMC 2174824. PMID 10831611. doi:10.1083/jcb.149.5.1073

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