MED23

MED23
Identificadores
Nomes alternativos	MED23, CRSP3
IDs externos	OMIM: 605042 HomoloGene: 3552 GeneCards: MED23
Ontologia genética
Função molecular	• GO:0001105 transcription coactivator activity; • GO:0001948, GO:0016582 ligação a proteínas plasmáticas;
Componente celular	• núcleo celular; • transcription regulator complex; • cariolinfa; • mediator complex;
Processo biológico	• GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • transcription initiation from RNA polymerase II promoter; • GO:0009373 regulation of transcription, DNA-templated; • transcription, DNA-templated; • positive regulation of nucleic acid-templated transcription; • GO:1901313 positive regulation of gene expression;
	Sources:Amigo / QuickGO
Padrão de expressão RNA
	Mais dados de referência de expressão
Ortólogos
	9439
	n/a
	ENSG00000112282
	n/a
	Q9ULK4
	n/a
	NM_001270521; NM_001270522; NM_004830; NM_015979
	n/a
NP_001257450; NP_001257451; NP_004821; NP_057063; NP_001363446;
	NP_001363447; NP_001363448; NP_001363449; NP_001363450; NP_001363451; NP_001363452; NP_001363453
	n/a
	Wikidata
Ver/Editar Humano

A Mediador da subunidade 23 de transcrição da RNA polimerase II é uma proteína secretora rica em cisteína que em humanos é codificada pelo gene MED23^[2]^[3] também conhecido como CRSP3.^[4]

Referências

↑ «Human PubMed Reference:»
↑ Ryu S, Zhou S, Ladurner AG, Tjian R (fevereiro de 1999). «The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1». Nature. 397 (6718): 446–50. PMID 9989412. doi:10.1038/17141
↑ «Entrez Gene: CRSP3 cofactor required for Sp1 transcriptional activation, subunit 3, 130kDa»
↑ Kang YK, Guermah M, Yuan CX, Roeder RG (março de 2002). «The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro». Proceedings of the National Academy of Sciences of the United States of America. 99 (5): 2642–7. PMC 122401. PMID 11867769. doi:10.1073/pnas.261715899

Leitura adicional

Rachez C, Lemon BD, Suldan Z, Bromleigh V, Gamble M, Näär AM, Erdjument-Bromage H, Tempst P, Freedman LP (abril de 1999). «Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex». Nature. 398 (6730): 824–8. PMID 10235266. doi:10.1038/19783
Näär AM, Beaurang PA, Zhou S, Abraham S, Solomon W, Tjian R (abril de 1999). «Composite co-activator ARC mediates chromatin-directed transcriptional activation». Nature. 398 (6730): 828–32. PMID 10235267. doi:10.1038/19789
Boyer TG, Martin ME, Lees E, Ricciardi RP, Berk AJ (maio de 1999). «Mammalian Srb/Mediator complex is targeted by adenovirus E1A protein». Nature. 399 (6733): 276–9. PMID 10353252. doi:10.1038/20466
Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (outubro de 1999). «Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro». DNA Research. 6 (5): 337–45. PMID 10574462. doi:10.1093/dnares/6.5.337
Ko L, Cardona GR, Chin WW (maio de 2000). «Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator». Proceedings of the National Academy of Sciences of the United States of America. 97 (11): 6212–7. PMC 18584. PMID 10823961. doi:10.1073/pnas.97.11.6212
Hartley JL, Temple GF, Brasch MA (novembro de 2000). «DNA cloning using in vitro site-specific recombination». Genome Research. 10 (11): 1788–95. PMC 310948. PMID 11076863. doi:10.1101/gr.143000
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (março de 2001). «Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs». Genome Research. 11 (3): 422–35. PMC 311072. PMID 11230166. doi:10.1101/gr.GR1547R
Stevens JL, Cantin GT, Wang G, Shevchenko A, Shevchenko A, Berk AJ (abril de 2002). «Transcription control by E1A and MAP kinase pathway via Sur2 mediator subunit». Science. 296 (5568): 755–8. PMID 11934987. doi:10.1126/science.1068943
Asada S, Choi Y, Yamada M, Wang SC, Hung MC, Qin J, Uesugi M (outubro de 2002). «External control of Her2 expression and cancer cell growth by targeting a Ras-linked coactivator». Proceedings of the National Academy of Sciences of the United States of America. 99 (20): 12747–52. PMC 130531. PMID 12242338. doi:10.1073/pnas.202162199
Nakayama M, Kikuno R, Ohara O (novembro de 2002). «Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs». Genome Research. 12 (11): 1773–84. PMC 187542. PMID 12421765. doi:10.1101/gr.406902
Goldberg SF, Miele ME, Hatta N, Takata M, Paquette-Straub C, Freedman LP, Welch DR (janeiro de 2003). «Melanoma metastasis suppression by chromosome 6: evidence for a pathway regulated by CRSP3 and TXNIP». Cancer Research. 63 (2): 432–40. PMID 12543799
Sato S, Tomomori-Sato C, Banks CA, Parmely TJ, Sorokina I, Brower CS, Conaway RC, Conaway JW (dezembro de 2003). «A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex». The Journal of Biological Chemistry. 278 (50): 49671–4. PMID 14576168. doi:10.1074/jbc.C300444200
Tomomori-Sato C, Sato S, Parmely TJ, Banks CA, Sorokina I, Florens L, Zybailov B, Washburn MP, Brower CS, Conaway RC, Conaway JW (fevereiro de 2004). «A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2». The Journal of Biological Chemistry. 279 (7): 5846–51. PMID 14638676. doi:10.1074/jbc.M312523200
Mo X, Kowenz-Leutz E, Xu H, Leutz A (janeiro de 2004). «Ras induces mediator complex exchange on C/EBP beta». Molecular Cell. 13 (2): 241–50. PMID 14759369. doi:10.1016/S1097-2765(03)00521-5
Sato S, Tomomori-Sato C, Parmely TJ, Florens L, Zybailov B, Swanson SK, Banks CA, Jin J, Cai Y, Washburn MP, Conaway JW, Conaway RC (junho de 2004). «A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology». Molecular Cell. 14 (5): 685–91. PMID 15175163. doi:10.1016/j.molcel.2004.05.006
Wada O, Oishi H, Takada I, Yanagisawa J, Yano T, Kato S (agosto de 2004). «BRCA1 function mediates a TRAP/DRIP complex through direct interaction with TRAP220». Oncogene. 23 (35): 6000–5. PMID 15208681. doi:10.1038/sj.onc.1207786
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (outubro de 2004). «From ORFeome to biology: a functional genomics pipeline». Genome Research. 14 (10B): 2136–44. PMC 528930. PMID 15489336. doi:10.1101/gr.2576704

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[1] «Human PubMed Reference:»

[pmid9989412-2] Ryu S, Zhou S, Ladurner AG, Tjian R (fevereiro de 1999). «The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1». Nature. 397 (6718): 446–50. PMID 9989412. doi:10.1038/17141

[entrez-3] «Entrez Gene: CRSP3 cofactor required for Sp1 transcriptional activation, subunit 3, 130kDa»

[pmid11867769-4] Kang YK, Guermah M, Yuan CX, Roeder RG (março de 2002). «The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro». Proceedings of the National Academy of Sciences of the United States of America. 99 (5): 2642–7. PMC 122401. PMID 11867769. doi:10.1073/pnas.261715899

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