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Predefinição
:
PBB/596
1 língua
Српски / srpski
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Origem: Wikipédia, a enciclopédia livre.
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Predefinição:PBB
B-cell CLL/lymphoma 2
Renderização
PDB
baseada em 1GJH,1G5M.
Estruturas disponíveis
PDB
Busca de ortólogos:
PDBe
,
RCSB
Lista de códigos PDB
1G5M
,
1GJH
,
1YSW
,
2O21
,
2O22
,
2O2F
,
2W3L
,
2XA0
,
4AQ3
,
4IEH
,
4LVT
,
4LXD
,
4MAN
Identificadores
Símbolos
BCL2
; Bcl-2; PPP1R50
IDs externos
OMIM:
151430
MGI
:
88138
HomoloGene
:
527
ChEMBL
:
4860
GeneCards
:
BCL2 Gene
Ontologia do gene
Função molecular
•
protease binding
•
protein binding
•
transcription factor binding
•
channel activity
•
channel inhibitor activity
•
ubiquitin protein ligase binding
•
identical protein binding
•
protein homodimerization activity
•
sequence-specific DNA binding
•
protein heterodimerization activity
•
BH3 domain binding
•
protein phosphatase 2A binding
Componente celular
•
nucleus
•
cytoplasm
•
mitochondrion
•
mitochondrial outer membrane
•
endoplasmic reticulum
•
endoplasmic reticulum membrane
•
cytosol
•
membrane
•
nuclear membrane
•
myelin sheath
•
pore complex
Processo biológico
•
protein polyubiquitination
•
response to acid
•
ossification
•
ovarian follicle development
•
metanephros development
•
branching involved in ureteric bud morphogenesis
•
behavioral fear response
•
B cell homeostasis
•
release of cytochrome c from mitochondria
•
regulation of cell-matrix adhesion
•
lymphoid progenitor cell differentiation
•
B cell lineage commitment
•
response to ischemia
•
renal system process
•
protein dephosphorylation
•
melanin metabolic process
•
regulation of nitrogen utilization
•
apoptotic process
•
humoral immune response
•
cellular response to DNA damage stimulus
•
actin filament organization
•
axonogenesis
•
female pregnancy
•
cell aging
•
male gonad development
•
extrinsic apoptotic signaling pathway via death domain receptors
•
intrinsic apoptotic signaling pathway in response to DNA damage
•
intrinsic apoptotic signaling pathway in response to oxidative stress
•
response to radiation
•
response to toxic substance
•
post-embryonic development
•
response to iron ion
•
response to UV-B
•
response to gamma radiation
•
negative regulation of autophagy
•
negative regulation of calcium ion transport into cytosol
•
regulation of glycoprotein biosynthetic process
•
mesenchymal cell development
•
positive regulation of neuron maturation
•
positive regulation of smooth muscle cell migration
•
cell growth
•
single organismal cell-cell adhesion
•
peptidyl-serine phosphorylation
•
peptidyl-threonine phosphorylation
•
cochlear nucleus development
•
gland morphogenesis
•
regulation of transmembrane transporter activity
•
negative regulation of ossification
•
positive regulation of cell growth
•
negative regulation of cell growth
•
melanocyte differentiation
•
negative regulation of cell migration
•
positive regulation of B cell proliferation
•
hair follicle morphogenesis
•
axon regeneration
•
regulation of protein stability
•
endoplasmic reticulum calcium ion homeostasis
•
glomerulus development
•
negative regulation of cellular pH reduction
•
negative regulation of myeloid cell apoptotic process
•
T cell differentiation in thymus
•
positive regulation of peptidyl-serine phosphorylation
•
negative regulation of osteoblast proliferation
•
response to cytokine
•
response to nicotine
•
organ growth
•
nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
•
positive regulation of multicellular organism growth
•
B cell proliferation
•
cellular response to glucose starvation
•
response to drug
•
response to hydrogen peroxide
•
T cell homeostasis
•
negative regulation of apoptotic process
•
positive regulation of catalytic activity
•
CD8-positive, alpha-beta T cell lineage commitment
•
regulation of protein homodimerization activity
•
regulation of protein heterodimerization activity
•
negative regulation of neuron apoptotic process
•
ear development
•
regulation of viral genome replication
•
innate immune response
•
positive regulation of melanocyte differentiation
•
negative regulation of mitotic cell cycle
•
negative regulation of retinal cell programmed cell death
•
regulation of mitochondrial membrane permeability
•
focal adhesion assembly
•
spleen development
•
thymus development
•
digestive tract morphogenesis
•
developmental growth
•
oocyte development
•
positive regulation of skeletal muscle fiber development
•
pigment granule organization
•
homeostasis of number of cells within a tissue
•
B cell receptor signaling pathway
•
response to glucocorticoid
•
neuron apoptotic process
•
defense response to virus
•
regulation of mitochondrial membrane potential
•
negative regulation of mitochondrial depolarization
•
regulation of calcium ion transport
•
transmembrane transport
•
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
•
cellular response to organic substance
•
cellular response to hypoxia
•
reactive oxygen species metabolic process
•
extrinsic apoptotic signaling pathway in absence of ligand
•
intrinsic apoptotic signaling pathway
•
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
•
negative regulation of G1/S transition of mitotic cell cycle
•
negative regulation of anoikis
•
negative regulation of apoptotic signaling pathway
•
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
•
negative regulation of intrinsic apoptotic signaling pathway
•
positive regulation of intrinsic apoptotic signaling pathway
Sources:
Amigo
/
QuickGO
Padrões de expressão do ARN
Mais dados de expressão
Ortólogos
Espécies
Humano
Rato
Entrez
596
12043
Ensembl
ENSG00000171791
ENSMUSG00000057329
UniProt
P10415
P10417
RefSeq (mRNA)
NM_000633
NM_009741
RefSeq (proteína)
NP_000624
NP_033871
Localização (UCSC)
Chr 18:
60.79 – 60.99 Mb
Chr 1:
106.54 – 106.71 Mb
Busca
PubMed
[1]
[2]
v
d
e
Categoria
:
Proteínas humanas