Usuário(a):MikutoH/T/1
Canais iônicos pred
[editar | editar código-fonte]modulation 5ht
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Binding profiles
[editar | editar código-fonte]Compound | SERT | NET | DAT | Type | Class | |
---|---|---|---|---|---|---|
Amfonelic acid | ND | ND | 207 | DRI | Stimulant | |
Amineptine*[2][3] | >100,000 (rat) | 10,000 (rat) | 1,000–1,400 (rat) | DRI | Stimulant | |
Amitriptyline | 4.30 | 35 | 3,250 | SNRI | TCA | |
Amoxapine | 58 | 16.0 | 4,310 | SNRI | TeCA | |
Amphetamine | >100,000 | ND | ND | NDRA | Stimulant | |
D-Amphetamine | >100,000 | 530 | 2,900 | NDRA | Stimulant | |
L-Amphetamine | >100,000 | ND | ND | NRA | Stimulant | |
Atomoxetine | 77 | 5 | 1,451 | NRI | Stimulant | |
Bupropion | 9,100 | 52,000 | 520 | NDRI | Stimulant | |
Butriptyline | 1,360 | 5,100 | 3,940 | N/A (IA) | TCA | |
Chlorphenamine | 15.2 | 1,440 | 1,060 | SRI | Antihistamine | |
Citalopram | 1.16 | 4,070 | 28,100 | SRI | SSRI | |
Escitalopram[4] | 1.1 | 7,841 | 27,410 | SRI | SSRI | |
Clomipramine | 0.28 | 38 | 2,190 | SNRI | TCA | |
Cocaethylene[5] | 3,878 | >10,000 | 555 | SDRI | Stimulant | |
Cocaine[5] | 304 | 779 | 478 | SNDRI | Stimulant | |
Cocaine[6] | 313±17 (IC50) | 292±34 (IC50) | 211±19 (IC50) | SNDRI | Stimulant | |
Desipramine | 17.6 | 0.83 | 3,190 | SNRI | TCA | |
Desmethylcitalopram | 3.6 | 1,820 | 18,300 | SRI | SSRI | |
Desmethylsertraline | 3.0 | 390 | 129 | SRI | SSRI | |
Desmethylsibutramine[7] | 15 | 20 | 49 | SNDRI | SNRI | |
(R)-Desmethylsibutramine | 44 | 4 | 12 | SNDRI | SNRI | |
(S)-Desmethylsibutramine | 9,200 | 870 | 180 | SNDRI | SNRI | |
Desoxypipradrol[8] | 53,700 | 550 | 50 | NDRI | Stimulant | |
Desvenlafaxine*[9] | 47 | 531 | ND | SNRI | SNRI | |
Didesmethylsibutramine[7] | 20 | 15 | 45 | SNDRI | SNRI | |
(R)-Didesmethylsibutramine | 140 | 13 | 8.9 | SNDRI | SNRI | |
(S)-Didesmethylsibutramine | 4,300 | 62 | 12 | SNDRI | SNRI | |
Diphenhydramine | 3,800 | 960 | 2,200 | N/A (IA) | Antihistamine | |
Dosulepin (dothiepin) | 8.6 | 46 | 5,310 | SNRI | TCA | |
Doxepin | 68 | 29.5 | 12,100 | SNRI | TCA | |
Duloxetine*[10] | 3.7 | 20 | 439 | SNRI | SNRI | |
Etoperidone | 890 | 20,000 | 52,000 | SRI | SARI | |
Femoxetine | 11.0 | 760 | 2,050 | SRI | SSRI | |
Fluoxetine | 0.81 | 240 | 3,600 | SRI | SSRI | |
Fluvoxamine | 2.2 | 1,300 | 9,200 | SRI | SSRI | |
GBR-12935[5] | 289 | 277 | 4.90 | DRI | Stimulant | |
Hydroxybupropion[11] | ND | 1.7 (IC50) | >10 (IC50) | NDRI | Stimulant | |
Imipramine | 1.40 | 37 | 8,500 | SNRI | TCA | |
Indatraline[5] | 3.10 | 12.6 | 1.90 | SNDRI | Stimulant | |
Iprindole | 1,620 | 1,262 | 6,530 | N/A (IA) | TCA | |
Lofepramine | 70 | 5.4 | 18,000 | SNRI | TCA | |
Maprotiline | 5,800 | 11.1 | 1,000 | NRI | TeCA | |
Mazindol | 39 | 0.45 | 8.1 | NDRI | Stimulant | |
MDPV[12] | 3,349 | 26 | 4.1 | NDRI | Stimulant | |
Methamphetamine | >100,000 | ND | ND | NDRA | Stimulant | |
D-Methamphetamine | >100,000 | 660 | 2,800 | NDRA | Stimulant | |
L-Methamphetamine | >100,000 | ND | ND | NRA | Stimulant | |
Methylphenidate | >10,000 | 788 | 121 | NDRI | Stimulant | |
D-Methylphenidate | >10,000 | 206 | 161 | NDRI | Stimulant | |
L-Methylphenidate | >6,700 | >10,000 | 2,250 | NDRI | Stimulant | |
Mianserin | 4,000 | 71 | 9,400 | NRI | TeCA | |
Milnacipran*[10] | 151 | 68 | >100,000 | SNRI | SNRI | |
Levomilnacipran*[13] | 19.0 | 10.5 | >100,000 | SNRI | SNRI | |
Mirtazapine | >100,000 | 4,600 | >100,000 | N/A (IA) | TeCA | |
Modafinil*[14] | >50,000 | 136,000 | 4,043 | DRI | Stimulant | |
Nefazodone | 200 | 360 | 360 | SNDRI | SARI | |
Nefopam[15] | 29 | 33 | 531 | SNDRI | Analgesic | |
Nisoxetine[5] | 427 | 2.3 | 1,235 | NRI | Stimulant | |
Nomifensine | 1,010 | 15.6 | 56 | NDRI | Stimulant | |
Norfluoxetine | 1.47 | 1,426 | 420 | SRI | SSRI | |
Nortriptyline | 18 | 4.37 | 1,140 | SNRI | TCA | |
Oxaprotiline | 3,900 | 4.9 | 4,340 | NRI | TeCA | |
Paroxetine | 0.13 | 40 | 490 | SRI | SSRI | |
Protriptyline | 19.6 | 1.41 | 2,100 | SNRI | TCA | |
Reboxetine[16] | 129 | 1.1 | >10,000 | NRI | Stimulant | |
Sertraline | 0.29 | 420 | 25 | SRI | SSRI | |
Sibutramine[7] | 298–2,800 | 350–5,451 | 943–1,200 | SNDRI | SNRI | |
Trazodone | 160 | 8,500 | 7,400 | SRI | SARI | |
Trimipramine | 149 | 2,450 | 3,780 | SRI | TCA | |
Vanoxerine[5] | 73.2 | 79.2 | 4.3 | DRI | Stimulant | |
Venlafaxine*[10] | 145 | 1,420 | 3,070 | SNRI | SNRI | |
Vilazodone*[17] | 0.2 | ~60 | ND | SRI | SMS | |
Viloxazine | 17,300 | 155 | >100,000 | NRI | Stimulant | |
Vortioxetine*[18] | 5.4 | 890 (rat) | 140 (rat) | SRI | SMS | |
Zimelidine | 152 | 9,400 | 11,700 | SRI | SSRI | |
Values are Ki (nM) or, in some cases (*), IC50 (nM). The smaller the value, the more strongly the drug binds to or inhibits the transporter. |
Infocaixes
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Nome da predefinição * nome_do_ficheiro.svg (e não [[nome_do_ficheiro.svg]] * tamanho da imagem (exemplo: ImageSize=100px, default=200px) * nome IUPAC * nome sistemático * outro nome Secção Identificadores - Números padrão, etc. * quaisquer abreviaturas * Número CAS, ligações a eMolecules * EINECS, ligações ao ecb; a URL é http://ecb.jrc.it/esis/index.php?GENRE=ECNO&ENTREE= * também EINECS, mas a URL é http://ecb.jrc.it/esis/index.php?GENRE=CASNO&ENTREE= * PubChem, ligações à pubchem, através do número CID (''Compound identification number''). Para passar a identificação do número SID (''Substance identification number''), utilizar o formato ''n/SID'', por exemplo, 96024416/SID * SMILES, sem ligações * InChI, sem ligações * RTECS, sem ligações * Medical Subject Headings, ligações à NIH * ChEBI, ligações ao EBI * KEGG, ligações a genome.ad.jp * prefixo ATCCode (primeiros três caracteres), ligação interna * sufixo ATCCode (últimos quatro caracteres), ligações ATC completas à WHO C.C. * Outros códigos ATC (use a predefinição {{ATC}}) * Banco de dados da Universidade de Alberta com dados a respeito de medicamentos Secção propriedades - propriedades físicas * fórmula molecular * massa molar, incluindo unidades * aparência física * densidade * ponto de fusão, incluindo unidades * notas sobre o ponto de fusão * ponto de ebulição, incluindo unidades * notas sobre o ponto de ebulição * solubilidade em água * solubilidade noutros solventes, usado em conjunto com o campo seguinte * em que solvente é solúvel * coeficiente de partição * pressão de vapor * constante da lei de Henry (kH) * Atmospheric OH rate constant * pKa * pKb Secção Estrutura - informação sobre a estrutura cristalina * Estrutura cristalina * Coordenação * Forma molecular Secção termoquímica - propriedades termoquímicas * Delta Hf * Delta Hc * Entropia * capacidade calorífica Secção farmacologia - dados farmacológicos * vias de administração * Biodisponibilidade * Metabolismo * Semi-vida * Ligação a proteínas * Excreção * estatuto legal * estatuto legal nos EUA * estatuto legal no Reino Unido * estatuto legal na Austrália * Legal status in CA * Pregnacy Category * Pregnacy Category in US * Pregnacy Category in AU Secção Explosivos - propriedades explosivas * sensibilidade a choques * sensibilidade a fricção * explosividade * factor RE Secção Perigos - perigos associados * Classe EU * Índice EU * Principais perigos * NFPA-H - Saúde * NFPA-F - Fogo * NFPA-R - Reactividade * NFPA-O - um dos parâmetros W, OX, COR, ALK, ACID, CRYO, RA, ou vazio * Frases R - use a predefinição {{R}} para este campo * Frases S - use a predefinição {{S}} para este campo * Frases R e S - ou use a combinação dos dois campos acima * ponto de fulgor * Autoignição * limites de explosividade * PEL * Dose letal mediana Secção Relacionados - Compostos relacionados, etc * outros aniões * outros catiões * outra função - funciona em conjunto com o campo seguinte * Função - a função extra * outros compostos - secção "ver também" -fim |
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clinical data
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| {{Chembox header|fundo=}} | <small>'''Exceto onde denotado, os dados referem-se a<br/> materiais sob [[condições normais de temperatura e pressão]]'''<br/>'''[[Wikipedia:Informação nas infocaixas de química|Referências e avisos gerais sobre esta caixa]].'''<br>'''[[Wikipedia:Aviso médico|Alerta sobre risco à saúde]].''' </small>
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- ↑ Tatsumi M, Groshan K, Blakely RD, Richelson E (1997). «Pharmacological profile of antidepressants and related compounds at human monoamine transporters» (PDF). Eur. J. Pharmacol. 340 (2–3): 249–58. PMID 9537821. doi:10.1016/s0014-2999(97)01393-9[ligação inativa]
- ↑ Ceci A, Garattini S, Gobbi M, Mennini T (1986). «Effect of long term amineptine treatment on pre- and postsynaptic mechanisms in rat brain». Br. J. Pharmacol. 88 (1): 269–75. PMC 1917102
. PMID 3708219. doi:10.1111/j.1476-5381.1986.tb09495.x
- ↑ Garattini S, Mennini T (1989). «Pharmacology of amineptine: synthesis and updating». Clin Neuropharmacol. 12 Suppl 2: S13–8. PMID 2698268. doi:10.1097/00002826-198912002-00003
- ↑ Owens JM, Knight DL, Nemeroff CB (2002). «[Second generation SSRIS: human monoamine transporter binding profile of escitalopram and R-fluoxetine]». Encephale (em francês). 28 (4): 350–5. PMID 12232544
- ↑ a b c d e f Rothman RB, Baumann MH (2003). «Monoamine transporters and psychostimulant drugs». Eur. J. Pharmacol. 479 (1–3): 23–40. PMID 14612135. doi:10.1016/j.ejphar.2003.08.054
- ↑ http://www.emcdda.europa.eu/system/files/publications/1814/TDAS15001ENN.pdf Predefinição:Bare URL PDF
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